Article
Association between polymorphisms in serine protease inhibitor, kazal type 5 and asthma phenotypes in a large German population sample.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Mar 2004
Kabesch M, Carr D, Weiland S K, von Mutius E
Abstract excerpt
BACKGROUND: Atopic diseases are characterized by immunoglobulin E (IgE)-mediated immune responses towards common allergens, many of which are proteases. Recently it has been suggested that a proteinase inhibitor gene, SPINK5, which is located on chromosome 5q31, may play a role in the pathogenesis of atopic diseases. OBJECTIVE: We investigated the association between the polymorphism G1258A leading to a putative...
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