Analysis of the individual and aggregate genetic contributions of previously identified serine peptidase inhibitor Kazal type 5 (SPINK5), kallikrein-related peptidase 7 (KLK7), and filaggrin (FLG) polymorphisms to eczema risk.

doi:10.1016/j.jaci.2008.05.050

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Article

Analysis of the individual and aggregate genetic contributions of previously identified serine peptidase inhibitor Kazal type 5 (SPINK5), kallikrein-related peptidase 7 (KLK7), and filaggrin (FLG) polymorphisms to eczema risk.

The Journal of allergy and clinical immunology - 1 Sept 2008

Weidinger Stephan, Baurecht Hansjörg, Wagenpfeil Stefan, Henderson John, Novak Natalija, Sandilands Aileen, Chen Huijia, Rodriguez Elke, O'Regan Grainne M, Watson Rosemarie, Liao Haihui, Zhao Yiwei, Barker Jonathan N W N, Allen Michael, Reynolds Nick, Meggitt Simon, Northstone Kate, Smith George D, Strobl Carolin, Stahl Caroline, Kneib Thomas, Klopp Norman, Bieber Thomas, Behrendt Heidrun, Palmer Colin N A, Wichmann H-Erich, Ring Johannes, Illig Thomas, McLean W H Irwin, Irvine Alan D

Abstract excerpt

BACKGROUND: Polymorphisms in the serine protease inhibitor gene serine peptidase inhibitor Kazal type 5 (SPINK5) and the serine protease kallikrein-related peptidase 7 gene (KLK7) appear to confer risk to eczema in some cohorts, but these findings have not been widely replicated. These genes encode proteins thought to be involved in the regulation of posttranslation processing of filaggrin (FLG), the strongest...

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Identifiers

PMID: 18774391
DOI: 10.1016/j.jaci.2008.05.050

Genes

SPINK5
FLG
KLK7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Analysis of the individual and aggregate genetic contributions of previously identified serine peptidase inhibitor Kazal type 5 (SPINK5), kallikrein-related peptidase 7 (KLK7), and filaggrin (FLG) polymorphisms to eczema risk.PMID 18774391Read ↗

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