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Article

Clinicopathologic correlations of liver kinase B1, E-cadherin, and N-cadherin expression in non-small cell lung cancer.

Applied immunohistochemistry & molecular morphology : AIMM - 1 Jul 2013

Liu Shuli, Miao Yuan, Fan Chuifeng, Liu Yang, Yu Juanhan, Zhang Yong, Dai Shundong, Wang Enhua

Abstract excerpt

The role of liver kinase B1 (LKB1) as a tumor suppressor has emerged from the observation of increased risk of malignancy in gastrointestinal tract in Peutz-Jeghers syndrome patients harboring LKB1 gene mutations. LKB1 gene inactivation has recently been demonstrated in a subset of lung carcinoma and has been proven to trigger epithelial-mesenchymal transition in lung adenocarcinoma cells. However, the...

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Identifiers

PMID: 23235348
DOI: 10.1097/PAI.0b013e31826b128b

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