Article
Titration of the gap junction protein Connexin43 reduces atherogenesis.
Thrombosis and haemostasis - 1 Aug 2014
Morel S, Chanson M, Nguyen T D, Glass A M, Richani Sarieddine M Z, Meens M J, Burnier L, Kwak B R, Taffet S M
Abstract excerpt
Ubiquitous reduction of the gap junction protein Connexin43 (Cx43) in mice provides beneficial effects on progression and composition of atherosclerotic lesions. Cx43 is expressed in multiple atheroma-associated cells but its function in each cell type is not known. To examine specifically the role of Cx43 in immune cells, we have lethally irradiated low-density lipoprotein receptor-deficient mice and...
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