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Modeling malaria in humanized mice: opportunities and challenges

11 Feb 2015

Abstract excerpt

About half of the world is at risk for developing malaria, which killed over 600,000 people in 2012 alone. The limited host range of the Plasmodium species that cause malaria in humans poses challenges for studying these parasites in experimentally tractable in vivo systems. To address this challenge, humanized mice have been constructed in which the tissue compartments relevant to the mammalian stages of...

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PMID: 25678404
DOI: 10.1111/nyas.12618

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