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Article

Ablation of osteopontin improves the skeletal phenotype of phospho1(-/-) mice.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Nov 2014

Yadav Manisha C, Huesa Carmen, Narisawa Sonoko, Hoylaerts Marc F, Moreau Alain, Farquharson Colin, Millán José Luis

Abstract excerpt

PHOSPHO1 and tissue-nonspecific alkaline phosphatase (TNAP) have nonredundant functions during skeletal mineralization. Although TNAP deficiency (Alpl(-/-) mice) leads to hypophosphatasia, caused by accumulation of the mineralization inhibitor inorganic pyrophosphate (PPi ), comparably elevated levels of PPi in Phospho1(-/-) mice do not explain their stunted growth, spontaneous fractures, bowed long bones,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24825455
DOI: 10.1002/jbmr.2281
PMCID: PMC5247257

Genes

PHOSPHO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Ablation of osteopontin improves the skeletal phenotype of phospho1(-/-) mice.PMID 24825455Read ↗

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