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Article

Compounded PHOSPHO1/ALPL deficiencies reduce dentin mineralization.

Journal of dental research - 1 Aug 2013

McKee M D, Yadav M C, Foster B L, Somerman M J, Farquharson C, Millán J L

Abstract excerpt

Phosphatases are involved in bone and tooth mineralization, but their mechanisms of action are not completely understood. Tissue-nonspecific alkaline phosphatase (TNAP, ALPL) regulates inhibitory extracellular pyrophosphate through its pyrophosphatase activity to control mineral propagation in the matrix; mice without TNAP lack acellular cementum, and have mineralization defects in dentin, enamel, and bone....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 23694930
DOI: 10.1177/0022034513490958
PMCID: PMC3711567

Genes

PHOSPHO1
ALPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Compounded PHOSPHO1/ALPL deficiencies reduce dentin mineralization.PMID 23694930Read ↗

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