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Article

Altered osteoclast development and function in osteopontin deficient mice.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 May 2008

Franzén Ahnders, Hultenby Kjell, Reinholt Finn P, Onnerfjord Patrik, Heinegård Dick

Abstract excerpt

The role of osteopontin in bone resorption was elucidated by studies of mice with knock out of the osteopontin gene generated by a different approach compared to previous models. Thus, a targeting vector with the promoter region as well as exons 1, 2, and 3 of the osteopontin gene was replaced by a loxP-flanked Neo-TK cassette, and this cassette was eliminated through transient expression of Cre recombinase. The...

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Identifiers

PMID: 18050311
DOI: 10.1002/jor.20544

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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