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Article

Osteoblast tissue-nonspecific alkaline phosphatase antagonizes and regulates PC-1.

American journal of physiology. Regulatory, integrative and comparative physiology - 1 Oct 2000

Johnson K A, Hessle L, Vaingankar S, Wennberg C, Mauro S, Narisawa S, Goding J W, Sano K, Millan J L, Terkeltaub R

Abstract excerpt

Tissue-nonspecific alkaline phosphatase (TNAP) is essential for bone matrix mineralization, but the central mechanism for TNAP action remains undefined. We observed that ATP-dependent (45)Ca precipitation was decreased in calvarial osteoblast matrix vesicle (MV) fractions from TNAP-/- mice, a model of infantile hypophosphatasia. Because TNAP hydrolyzes the mineralization inhibitor inorganic pyrophosphate (PP(i)),...

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Identifiers

PMID: 11004006
DOI: 10.1152/ajpregu.2000.279.4.R1365

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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