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Article

Deficiency of the bone mineralization inhibitor NPP1 protects mice against obesity and diabetes.

Disease models & mechanisms - 1 Dec 2014

Huesa Carmen, Zhu Dongxing, Glover James D, Ferron Mathieu, Karsenty Gerard, Milne Elspeth M, Millan José Luis, Ahmed S Faisal, Farquharson Colin, Morton Nicholas M, MacRae Vicky E

Abstract excerpt

The emergence of bone as an endocrine regulator has prompted a re-evaluation of the role of bone mineralization factors in the development of metabolic disease. Ectonucleotide pyrophosphatase/phosphodiesterase-1 (NPP1) controls bone mineralization through the generation of pyrophosphate, and levels of NPP1 are elevated both in dermal fibroblast cultures and muscle of individuals with insulin resistance. We...

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Identifiers

PMID: 25368121
DOI: 10.1242/dmm.017905
PMCID: PMC4257003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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