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Article

[Optimization of hydroxylating DHEA to 7alpha,15alpha-diOH-DHEA by compound mutation and fermentation optimization].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology - 1 Jan 2014

Li Chuanpeng, Li Hui, Wu Yan, Li Heng, Zhang Rujin, Zhang Zhengbin, Shi Jinsong, Xu Zhenghong

Abstract excerpt

Combined with method of ketoconazole resistance screening, a 7alpha,15alpha-diOH-DHEA high-producing mutant Colletotrichum lini ST-1 was obtained by compound mutation of NTG and low energy N+ ion beam implantation. With the substrate concentration of 10 g/L DHEA, the molar yield of 7alpha,15alpha-diOH-DHEA reached 34.2%, increased by 46.2% than that of the original strain. Then we optimized the medium. First,...

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PMID: 24818489

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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