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Mutation breeding of high 4-androstene-3,17-dione-producing Mycobacterium neoaurum ZADF-4 by atmospheric and room temperature plasma treatment.

Journal of Zhejiang University. Science. B - 1 Apr 2015

Liu Chao, Zhang Xian, Rao Zhi-ming, Shao Ming-long, Zhang Le-le, Wu Dan, Xu Zheng-hong, Li Hui

Abstract excerpt

Steroid medication is used extensively in clinical applications and comprises a large and vital part of the pharmaceutical industry. However, the difficulty of separating 4-androstene-3,17-dione (AD) from 1,4-androstadiene-3,17-dione (ADD) restricts the application of the microbial transformation of phytosterols in the industry. A novel atmospheric and room temperature plasma (ARTP) treatment, which employs...

Topics

Androstenedione
Atmosphere
Genetic Enhancement
Mutation
Mycobacterium
Plasma Gases
Species Specificity
Temperature

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 25845362
DOI: 10.1631/jzus.B1400274
PMCID: PMC4399429

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Mutation breeding of high 4-androstene-3,17-dione-producing Mycobacterium neoaurum ZADF-4 by atmospheric and room temperature plasma treatment.PMID 25845362Read ↗

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