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[Mutation breeding of high 9α-hydroxy-androst-4-ene-3,17- dione transforming strains from phytosterols and their conversion process optimization].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology - 25 Jul 2017

Ma Yang, Wang Xiangdong, Wang Menghui, Li Hui, Shi Jinsong, Xu Zhenghong

Abstract excerpt

In order to improve transformation efficiency of phytosterols into 9α-hydroxylation of 4-androstene-3,17-dione (9α-OH-AD) by Mycobacterium sp. LY-1, we studied the strains breeding using atmospheric and room temperature plasma (ARTP) technology and optimized their conversion process. A high production strain named C33 with a good genetic stability was selected and the product molar yield reached to 15.5%, 34.8%...

Topics

Androstenedione
Biotransformation
Fermentation
Industrial Microbiology
Mutation
Mycobacterium
Phytosterols

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 28869739
DOI: 10.13345/j.cjb.170014

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