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Article

Computational studies of anaplastic lymphoma kinase mutations reveal common mechanisms of oncogenic activation.

Proceedings of the National Academy of Sciences of the United States of America - 9 Mar 2021

Patil Keshav, Jordan Earl Joseph, Park Jin H, Suresh Krishna, Smith Courtney M, Lemmon Abigail A, Mossé Yaël P, Lemmon Mark A, Radhakrishnan Ravi

Abstract excerpt

Kinases play important roles in diverse cellular processes, including signaling, differentiation, proliferation, and metabolism. They are frequently mutated in cancer and are the targets of a large number of specific inhibitors. Surveys of cancer genome atlases reveal that kinase domains, which consist of 300 amino acids, can harbor numerous (150 to 200) single-point mutations across different patients in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33674381
DOI: 10.1073/pnas.2019132118
PMCID: PMC7958353

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