Article
Variation in N-acetyltransferase 2 (NAT2), smoking and risk of prostate cancer in the Slovak population.
Medical oncology (Northwood, London, England) - 1 Jun 2014
Vilčková Marta, Jurečeková Jana, Dobrota Dušan, Habalová Viera, Klimčáková Lucia, Waczulíková Iveta, Slezák Peter, Kliment Ján, Sivoňová Monika Kmeťová
Abstract excerpt
N-acetyltransferase 2 (NAT2) is an enzyme involved in the biotransformation of xenobiotics, mainly aromatic and heterocyclic amines and hydrazines, all of which represent an important class of carcinogens found in tobacco smoke. Polymorphism in NAT2 gene is reported to be associated with susceptibility to various types of cancer. This study investigated the relationship between the NAT2 polymorphism and the risk...
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