Article
N-acetyltransferase-2 gene polymorphisms and prostate cancer susceptibility in Latin American patients.
Medical oncology (Northwood, London, England) - 1 Dec 2012
de Lima Junior Mario Maciel, Reis Leonardo Oliveira, Guilhen Ana Carolina Trindade, Granja Fabiana, de Lima Oliveira Mariana Nicolau, Ferreira Ubirajara, Cunha Lucas Leite, Ward Laura Sterian
Abstract excerpt
We investigated the role of N-acetyltransferases (NAT) in prostate cancer (PCa) susceptibility. NAT are polymorphic in the population and metabolize important carcinogenic products directly involved in the tumor initiation process. This prospective case-control study utilized the polymerase chain reaction-based restriction fragment length polymorphism method and comprised a cohort of consecutive 478 individuals:...
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