Article
Association of prostate cancer with rapid N-acetyltransferase 1 (NAT1*10) in combination with slow N-acetyltransferase 2 acetylator genotypes in a pilot case-control study.
Environmental and molecular mutagenesis - 1 Jan 2002
Hein David W, Leff Matthew A, Ishibe Naoko, Sinha Rashmi, Frazier Harold A, Doll Mark A, Xiao Gong H, Weinrich Martin C, Caporaso Neil E
Abstract excerpt
N-acetyltransferase-1 (NAT1) and N-acetyltransferase-2 (NAT2) are important in the metabolism of aromatic and heterocyclic amine carcinogens that induce prostate tumors in the rat. We investigated the association of genetic polymorphisms in NAT1 and NAT2, alone and in combination, with human prostate cancer. Incident prostate cancer cases and controls in a hospital-based case-control study were frequency-matched...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.