Article
Fitness is strongly influenced by rare mutations of large effect in a microbial mutation accumulation experiment.
Genetics - 1 Jul 2014
Heilbron Karl, Toll-Riera Macarena, Kojadinovic Mila, MacLean R Craig
Abstract excerpt
Our understanding of the evolutionary consequences of mutation relies heavily on estimates of the rate and fitness effect of spontaneous mutations generated by mutation accumulation (MA) experiments. We performed a classic MA experiment in which frequent sampling of MA lines was combined with whole genome resequencing to develop a high-resolution picture of the effect of spontaneous mutations in a hypermutator...
Topics
- Bacterial Proteins
- DNA, Intergenic
- Genes, Bacterial
- Genetic Fitness
- INDEL Mutation
- Mutagenesis
- Mutation
- Open Reading Frames
- Pseudomonas aeruginosa
- Selection, Genetic