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Article

Stoichiometry of the eIF2B complex is maintained by mutual stabilization of subunits.

The Biochemical journal - 1 Mar 2016

Wortham Noel C, Stewart Joanna D, Harris Sean, Coldwell Mark J, Proud Christopher G

Abstract excerpt

The eukaryotic translation initiation factor eIF2B is a multi-subunit complex with a crucial role in the regulation of global protein synthesis in the cell. The complex comprises five subunits, termed α through ε in order of increasing size, arranged as a heterodecamer with two copies of each subunit. Regulation of the co-stoichiometric expression of the eIF2B subunits is crucial for the proper function and...

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PMID: 26614765
DOI: 10.1042/BJ20150828

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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