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Article

eIF2B, a mediator of general and gene-specific translational control.

Biochemical Society transactions - 1 Dec 2005

Pavitt G D

Abstract excerpt

eIF2B (eukaryotic initiation factor 2B) is a multisubunit protein that is required for protein synthesis initiation and its regulation in all eukaryotic cells. Mutations in eIF2B have also recently been found to cause a fatal human disease called CACH (childhood ataxia with central nervous system hypomyelination) or VWM (vanishing white matter disease). This review provides a general background to translation...

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PMID: 16246152
DOI: 10.1042/BST0331487

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eIF2B, a mediator of general and gene-specific translational control.PMID 16246152Read ↗

eIF2B: recent structural and functional insights into a key regulator of translation.Semantic proximity Read ↗

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eIF2B Activator Rescues Neonatal Lethality of an eIF2Bα Sugar Phosphate Binding Mutation Associated with Vanishing White Matter DiseaseSemantic proximity Read ↗

Mutational analysis of the alpha subunit of eIF2B provides insights into the role of eIF2B bodies in translational control and VWM disease.Semantic proximity Read ↗

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Analysis of the subunit organization of the eIF2B complex reveals new insights into its structure and regulation.Semantic proximity Read ↗

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