Article
Evidence for different expression profiles for c-Met, EGFR, PTEN and the mTOR pathway in low and high grade endometrial carcinomas in a cohort of consecutive women. Occurrence of PIK3CA and K-Ras mutations and microsatellite instability.
Histology and histopathology - 1 Nov 2014
Thoury Anne, Descatoire Véronique, Kotelevets Larissa, Kannengiesser Caroline, Bertrand Guylène, Theou-Anton Nathalie, Frey Caroline, Genestie Catherine, Raymond Eric, Chastre Eric, Lehy Thérèse, Walker Francine
Abstract excerpt
Molecular and genetic investigations in endometrial carcinogenesis may have prognostic and therapeutic implications. We studied the expression of EGFR, c-Met, PTEN and the mTOR signalling pathway (phospho-AKT/phospho-mTOR/phospho-RPS6) in 69 consecutive tumours and 16 tissue microarrays. We also analysed PIK3CA, K-Ras mutations and microsatellite instability (MSI). We distinguished two groups: group 1 (grade 1...
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