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Article

Molecular determinants of outcome with mammalian target of rapamycin inhibition in endometrial cancer.

Cancer - 15 Feb 2014

Mackay Helen J, Eisenhauer Elizabeth A, Kamel-Reid Suzanne, Tsao Ming, Clarke Blaise, Karakasis Katherine, Werner Henrica M J, Trovik Jone, Akslen Lars A, Salvesen Helga B, Tu Dongsheng, Oza Amit M

Abstract excerpt

BACKGROUND: Targeting the phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway is of increasing interest as a therapeutic strategy in many tumors. The aim of this study was to identify molecular markers associated with mTOR inhibitor activity in women with metastatic endometrial cancer. METHODS: Archival tumor samples were collected from 94 women with recurrent or metastatic...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 24166148
DOI: 10.1002/cncr.28414

Genes

PTEN
KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Molecular determinants of outcome with mammalian target of rapamycin inhibition in endometrial cancer.PMID 24166148Read ↗

The search continues: looking for predictive biomarkers for response to mammalian target of rapamycin inhibition in endometrial cancer.Semantic proximity Read ↗

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Combined targeting of FGFR2 and mTOR by ponatinib and ridaforolimus results in synergistic antitumor activity in FGFR2 mutant endometrial cancer models.Semantic proximity Read ↗

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