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Article

The stringent response and cell cycle arrest in Escherichia coli.

PLoS genetics - 1 Dec 2008

Ferullo Daniel J, Lovett Susan T

Abstract excerpt

The bacterial stringent response, triggered by nutritional deprivation, causes an accumulation of the signaling nucleotides pppGpp and ppGpp. We characterize the replication arrest that occurs during the stringent response in Escherichia coli. Wild type cells undergo a RelA-dependent arrest after treatment with serine hydroxamate to contain an integer number of chromosomes and a replication origin-to-terminus...

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Identifiers

PMID: 19079575
DOI: 10.1371/journal.pgen.1000300
PMCID: PMC2586660

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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