Article
The stringent response and cell cycle arrest in Escherichia coli.
PLoS genetics - 1 Dec 2008
Ferullo Daniel J, Lovett Susan T
Abstract excerpt
The bacterial stringent response, triggered by nutritional deprivation, causes an accumulation of the signaling nucleotides pppGpp and ppGpp. We characterize the replication arrest that occurs during the stringent response in Escherichia coli. Wild type cells undergo a RelA-dependent arrest after treatment with serine hydroxamate to contain an integer number of chromosomes and a replication origin-to-terminus...
Topics
- Bacterial Outer Membrane Proteins
- Cell Cycle
- Chromosome Segregation
- Chromosomes, Bacterial
- DNA-Binding Proteins
- Escherichia coli
- Escherichia coli Proteins
- Mutation
- Origin Recognition Complex
- Replication Origin
- Site-Specific DNA-Methyltransferase (Adenine-Specific)