Identification of functional haplotypes in the promoter region of the LST1 gene.

Abstract excerpt

Psoriasis, an inflammatory skin disease, was associated with a promoter variant (rs9267502; P = 3.786 × 10(-19)) of LST1 that may regulate immune response and cellular morphogenesis. Promoter activity was examined to identify functional variants in the proximity of the associated variant. Five natural haplotypes (H1-H5) of four variants (rs7758790, rs9267502, rs41268884, rs17200775) in strong linkage...