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Specificity protein 1 regulates topoisomerase IIβ expression in SH‐SY5Y cells during neuronal differentiation

7 May 2014

Abstract excerpt

Topoisomerase IIβ (top IIβ) is a nuclear enzyme with an essential role in neural development. The regulation of top IIβ gene expression during neural differentiation is poorly understood. Functional analysis of top IIβ gene structure displayed a GC box sequence in its transcription promoter, which binds the nuclear transcription factor specificity protein 1 (Sp1). Sp1 regulates gene expression via multiple...

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PMID: 24801450
DOI: 10.1002/jnr.23403

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