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Specificity Protein Transcription Factors and Cancer: Opportunities for Drug Development

15 Mar 2018

Abstract excerpt

Abstract Specificity protein (Sp) transcription factors (TFs) such as Sp1 are critical for early development but their expression decreases with age and there is evidence that transformation of normal cells to cancer cells is associated with upregulation of Sp1, Sp3, and Sp4, which are highly expressed in cancer cells and tumors. Sp1 is a negative prognostic factor for pancreatic, colon, glioma, gastric, breast,...

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PMID: 29545399
DOI: 10.1158/1940-6207.capr-17-0407

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