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Article

CRABP‐II methylation: A critical determinant of retinoic acid resistance of medulloblastoma cells

25 Nov 2011

Abstract excerpt

Medulloblastoma cells exhibit varied responses to therapy by all-trans retinoic acid (RA). The underlying mechanism for such diverse effects however remains largely unclear. In this study, we attempted to elucidate the molecular basis of RA resistance through the study of RA signaling components in both RA-sensitive (Med-3) and RA-resistant (UW228-2 and UW228-3) medulloblastoma cells. The results revealed that...

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PMID: 22153617
DOI: 10.1016/j.molonc.2011.11.004

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