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Article

Tetramethylpyrazine induces SH-SY5Y cell differentiation toward the neuronal phenotype through activation of the PI3K/Akt/Sp1/TopoIIβ pathway.

European journal of cell biology - 1 Dec 2015

Yan Yong-Xin, Zhao Jun-Xia, Han Shuo, Zhou Na-Jing, Jia Zhi-Qiang, Yao Sheng-Jie, Cao Cui-Li, Wang Yan-Ling, Xu Yan-Nan, Zhao Juan, Yan Yun-Li, Cui Hui-Xian

Abstract excerpt

Tetramethylpyrazine (TMP) is an active compound extracted from the traditional Chinese medicinal herb Chuanxiong. Previously, we have shown that TMP induces human SH-SY5Y neuroblastoma cell differentiation toward the neuronal phenotype by targeting topoisomeraseIIβ (TopoIIβ), a protein implicated in neural development. In the present study, we aimed to elucidate whether the transcriptional factors specificity...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26518113
DOI: 10.1016/j.ejcb.2015.09.001

Genes

MAP2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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