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Deleterious RAD51C germline mutations rarely predispose to breast and ovarian cancer in Pakistan.

Breast cancer research and treatment - 1 Jun 2014

Rashid Muhammad U, Muhammad Noor, Faisal Saima, Amin Asim, Hamann Ute

Abstract excerpt

RAD51C plays a key role in homologous recombination-mediated DNA repair and maintenance of genomic stability. Biallelic RAD51C mutations cause Fanconi anemia, and monoallelic mutations predispose women to breast and ovarian cancer. Genetic variability of RAD51C and its impact in Asian populations have been poorly studied. Here, we report the results of comprehensive mutational screening of the RAD51C gene in 348...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24800917
DOI: 10.1007/s10549-014-2972-0

Genes

BRCA1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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