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Article

Germline RAD51C mutations in ovarian cancer susceptibility.

Clinical genetics - 1 Apr 2013

Coulet F, Fajac A, Colas C, Eyries M, Dion-Minière A, Rouzier R, Uzan S, Lefranc J-P, Carbonnel M, Cornelis F, Cortez A, Soubrier F

Abstract excerpt

Several genes might explain BRCA1/2 negative breast and ovarian family cases. Deleterious mutations in few genes involved in the Fanconi complex are responsible for Fanconi anemia at the homozygous state and breast cancer (BC) susceptibility at the heterozygous state (BRCA2, PALB2, BRIP1). RAD51C plays an important role in the double-strand break repair pathway and a biallelic missense mutation in the RAD51C gene...

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Share to BRCA1 Protein
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22725699
DOI: 10.1111/j.1399-0004.2012.01917.x

Genes

BRCA1
BRCA2
BRIP1
PALB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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Germline RAD51C mutations in ovarian cancer susceptibility.PMID 22725699Read ↗

Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene.Semantic proximity Read ↗

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Germline mutations in RAD51C and RAD51D and hereditary predisposition to ovarian cancer.Semantic proximity Read ↗

Further evidence for the contribution of the RAD51C gene in hereditary breast and ovarian cancer susceptibility.Semantic proximity Read ↗

Deleterious RAD51C germline mutations rarely predispose to breast and ovarian cancer in Pakistan.Semantic proximity Read ↗

About 1% of the breast and ovarian Spanish families testing negative for BRCA1 and BRCA2 are carriers of RAD51D pathogenic variants.Semantic proximity Read ↗

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