Article
Identification of six pathogenic RAD51C mutations via mutational screening of 1228 Danish individuals with increased risk of hereditary breast and/or ovarian cancer.
Breast cancer research and treatment - 1 Jan 2016
Jønson Lars, Ahlborn Lise B, Steffensen Ane Y, Djursby Malene, Ejlertsen Bent, Timshel Susanne, Nielsen Finn C, Gerdes Anne-Marie, Hansen Thomas V O
Abstract excerpt
Germ-line mutations in the RAD51C gene have recently been identified in families with breast and ovarian cancer and have been associated with an increased risk of ovarian cancer. In this study, we describe the frequency of pathogenic RAD51C mutations identified in Danish breast and/or ovarian cancer families. We screened the RAD51C gene in 1228 Danish hereditary breast and/or ovarian cancer families by...
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