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Article

Prosurvival function of the cellular apoptosis susceptibility/importin-α1 transport cycle is repressed by p53 in liver cancer.

Hepatology (Baltimore, Md.) - 1 Sept 2014

Winkler Juliane, Ori Alessandro, Holzer Kerstin, Sticht Carsten, Dauch Daniel, Eiteneuer Eva Maria, Pinna Federico, Geffers Robert, Ehemann Volker, Andres-Pons Amparo, Breuhahn Kai, Longerich Thomas, Bermejo Justo Lorenzo, Gretz Norbert, Zender Lars, Schirmacher Peter, Beck Martin, Singer Stephan

Abstract excerpt

UNLABELLED: Proteins of the karyopherin superfamily including importins and exportins represent an essential part of the nucleocytoplasmic transport machinery. However, the functional relevance and regulation of karyopherins in hepatocellular carcinoma (HCC) is poorly understood. Here we identified cellular apoptosis susceptibility (CAS, exportin-2) and its transport substrate importin-α1 (imp-α1) among...

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Share to alpha Karyopherins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24799195
DOI: 10.1002/hep.27207

Genes

XIAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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