Article
A novel interaction of nucleophosmin with BCL2-associated X protein regulating death evasion and drug sensitivity in human hepatoma cells.
Hepatology (Baltimore, Md.) - 1 May 2013
Lo Shao-Jung, Fan Li-Ching, Tsai Yow-Fu, Lin Kuo-Yang, Huang Hsiao-Ling, Wang Tong-Hong, Liu Hsuan, Chen Tse-Chin, Huang Shiu-Fen, Chang Chee-Jen, Lin Yu-Jr, Yung Benjamin Yat-Ming, Hsieh Sen-Yung
Abstract excerpt
UNLABELLED: Death evasion is crucial for both carcinogenesis and resistance to anticancer therapies. Recently, we identified nucleophosmin (NPM) as a key factor counteracting death stimuli in human hepatocellular carcinoma (HCC) cells. Here we report the identification of a novel NPM-BCL2-associated X protein (BAX) pathway orchestrating death evasion in human HCC cells. Silencing of NPM expression significantly...
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