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Article

Deciphering ADME genetic data using an automated haplotype approach.

Pharmacogenetics and genomics - 1 Jun 2014

Guo Yingying, Farmen Mark W, Jin Yan, Lee Hsiu-Yung C, Penny Michelle A, Hillgren Kathleen M, Fossceco Stewart L

Abstract excerpt

OBJECTIVE: To investigate the utility of statistical tools in translating Affymetrix Drug Metabolizing Enzyme and Transporter (DMET) Assay single-nucleotide polymorphisms (SNPs) into common consensus star alleles. METHODS: DMET SNP data from clinical trials in different ethnicities were pooled for analyses. Three different statistical methods, PHASE, Bayesian, and expectation-maximization (EM), were first...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 24797890
DOI: 10.1097/FPC.0000000000000047

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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