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Article

GenoStaR: An R Package for Genotype to Star Allele Conversion for Major Cytochrome P450 Family of Genes.

Clinical pharmacology and therapeutics - 1 Jan 2026

Coulter Alex J, Thamilselvan Megana, Kennedy James L, Zai Clement C, Tiwari Arun K

Abstract excerpt

Pharmacogenomics enables the personalization of drug therapy by linking genetic variations to differences in drug metabolism, efficacy, and risk of adverse reactions. Genetic polymorphisms within cytochrome P450 (CYP) genes significantly affect enzyme activity, influencing drug plasma levels, responses, and safety. Central to this process is accurate genotype-to-phenotype translation, especially for the CYP...

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Topics

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Share to Alleles
Share to Cytochrome P-450 Enzyme System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CYP2C9 gene

Share to Genotype

Share to Pharmacogenetics

Share to Phenotype

Share to Polymorphism, Single Nucleotide

Share to Precision Medicine

Source

Open in PubMed Open full text

Identifiers

PMID: 40908856
DOI: 10.1002/cpt.70059
PMCID: PMC12746511

Genes

CYP1A2
CYP2B6
CYP2C19
CYP2C9
CYP3A4
CYP3A5
IMPACT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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