A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity

Abstract excerpt

Mutations in LRRK2 are one of the primary genetic causes of Parkinson's disease (PD). LRRK2 contains a kinase and a GTPase domain, and familial PD mutations affect both enzymatic activities. However, the signaling mechanisms regulating LRRK2 and the pathogenic effects of familial mutations remain unknown. Identifying the signaling proteins that regulate LRRK2 function and toxicity remains a critical goal for the...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Fungal and yeast genetics research
• Share to Parkinson's Disease Mechanisms and Treatments
• Share to Plant Gene Expression Analysis