Article
Loss of p19ARF enhances the defects of Mdm2 overexpression in the mammary gland.
Oncogene - 16 May 2002
Foster Carolyn J, Lozano Guillermina
Abstract excerpt
The protein encoded by the murine double minute 2 (Mdm2) gene inactivates the function of the tumor suppressor p53. The targeted expression of the mdm2 transgene (BLGmdm2) to the mammary epithelium disrupts the cell cycle, causing multiple rounds of DNA synthesis without proper cell division and...
Topics
- Animals
- Cell Cycle
- Cyclin-Dependent Kinase Inhibitor p16
- DNA Replication
- Epithelial Cells
- Female
- Giant Cells
- Lactation
- Mammary Glands, Animal
- Mice
- Mice, Knockout
- Mice, Transgenic
- Nuclear Proteins
- Phenotype
- Pregnancy
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-mdm2
- Tumor Suppressor Protein p14ARF