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Article

Loss of p19ARF enhances the defects of Mdm2 overexpression in the mammary gland.

Oncogene - 16 May 2002

Foster Carolyn J, Lozano Guillermina

Abstract excerpt

The protein encoded by the murine double minute 2 (Mdm2) gene inactivates the function of the tumor suppressor p53. The targeted expression of the mdm2 transgene (BLGmdm2) to the mammary epithelium disrupts the cell cycle, causing multiple rounds of DNA synthesis without proper cell division and consequently poor mammary gland development. These phenotypes in the mammary epithelia of the transgenic mice are not...

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Source

Identifiers

PMID: 12032854
DOI: 10.1038/sj.onc.1205441

Genes

E2F1
MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Loss of p19ARF enhances the defects of Mdm2 overexpression in the mammary gland.PMID 12032854Read ↗

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