Article
Identification of genetic variants of lecithin cholesterol acyltransferase in individuals with high HDL‑C levels.
Molecular medicine reports - 1 Jul 2014
Naseri Mohsen, Hedayati Mehdi, Daneshpour Maryam Sadat, Bandarian Fatemeh, Azizi Fereidoun
Abstract excerpt
Among the most common lipid abnormalities, a low level of high-density lipoprotein-cholesterol (HDL‑C) is one of the first risk factors identified for coronary heart disease. Lecithin cholesterol acyltransferase (LCAT) has a pivotal role in the formation and maturation of HDL-C and in reverse cholesterol transport. To identify genetic loci associated with low HDL-C in a population-based cohort in Tehran, the...
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