Article
Premature and severe cardiovascular disease in a Mexican male with markedly low high-density-lipoprotein-cholesterol levels and a mutation in the lecithin:cholesterol acyltransferase gene: a family study.
International journal of molecular medicine - 1 Jun 2014
Posadas-Sánchez Rosalinda, Posadas-Romero Carlos, Ocampo-Arcos Wendy Angélica, Villarreal-Molina María Teresa, Vargas-Alarcón Gilberto, Antúnez-Argüelles Erika, Mendoza-Pérez Enrique, Cardoso-Saldaña Guillermo, Martínez-Alvarado Rocío, Medina-Urrutia Aída, Jorge-Galarza Esteban
Abstract excerpt
Epidemiological and clinical studies have shown that a low plasma high‑density lipoprotein cholesterol (HDL-C) level is a strong predictor of cardiovascular disease (CVD). Lecithin:cholesterol acyltransferase (LCAT) is a key enzyme in the formation, maturation and function of HDL. Therefore impaired LCAT function may enhance atherosclerosis because of defective cholesterol transport. In this study, we examined a...
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