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Article

Genetic lecithin:cholesterol acyltransferase deficiency and cardiovascular disease.

Atherosclerosis - 1 Jun 2012

Calabresi Laura, Simonelli Sara, Gomaraschi Monica, Franceschini Guido

Abstract excerpt

The lecithin:cholesterol acyltransferase (LCAT) enzyme is responsible for the synthesis of cholesteryl esters in human plasma and plays a critical role in high density lipoprotein (HDL) metabolism. Genetic LCAT deficiency is a rare metabolic disorder characterized by low HDL cholesterol levels. This paper reviews the genetic and biochemical features of LCAT deficiency, highlighting the absence of enhanced...

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Source

Identifiers

PMID: 22189200
DOI: 10.1016/j.atherosclerosis.2011.11.034

Genes

LCAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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