Article
Effects of lecithin: cholesterol acyltransferase genotypes, enzyme levels, and activity on high-density lipoprotein levels.
Journal of clinical lipidology - 1 Jan 2000
Agirbasli Deniz, Cirakoglu Beyazit, Eren Fatih, Sumerkan Mutlu, Aksoy Sukru, Aral Cenk, Agirbasli Mehmet
Abstract excerpt
BACKGROUND: Lecithin:cholesterol acyltransferase (LCAT) is one of the key enzymes controlling cholesterol homeostasis and plays a primary role in high-density lipoprotein cholesterol (HDL-C) maturation. OBJECTIVE: The aim of our study was to evaluate the effects of LCAT gene polymorphisms 511C/T (exon4), 4886C/T (rs5923), and 608C/T (rs5922) on LCAT enzyme level, activity, and HDL-C levels. METHODS: The study...
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