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Article

Liver X receptor gene polymorphisms in tuberculosis: effect on susceptibility.

PloS one - 1 Jan 2014

Han Min, Liang Li, Liu Li-Rong, Yue Jun, Zhao Yan-Lin, Xiao He-Ping

Abstract excerpt

OBJECTIVES: The Liver X receptors (LXRs), Liver X receptor A (LXRA) and Liver X receptor B (LXRB), regulate lipid metabolism and antimicrobial response. LXRs have a crucial role in the control of Mycobacterium tuberculosis (M.tb). Lacking LXRs mice is more susceptibility to infection M.tb, developing higher bacterial burdens and an increase in the size and number of granulomatous lesions. We aimed to assess the...

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Identifiers

PMID: 24788534
DOI: 10.1371/journal.pone.0095954
PMCID: PMC4006844

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Source receipt: pubmed, retrieved 7 Sept 2026.

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