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Article

Treatment strategies for mosaic overgrowth syndromes of the PI3K-AKT-mTOR pathway.

British medical bulletin - 16 Dec 2021

Morin Gabriel, Canaud Guillaume

Abstract excerpt

INTRODUCTION OR BACKGROUND: Mosaic overgrowth syndromes (OS) are a proteiform ensemble of rare diseases displaying asymmetric overgrowth involving any tissue type, with degrees of severity ranging from isolated malformation to life-threatening conditions such as pulmonary embolism. Despite discordant clinical presentations, all those syndromes share common genetic anomalies: somatic mutations of genes involved in...

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Share to Proto-Oncogene Proteins c-akt

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to TOR Serine-Threonine Kinases

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PMID: 34530449
DOI: 10.1093/bmb/ldab023

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