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Article

Relationship between Interleukin-6 gene polymorphism and hippocampal volume in antipsychotic-naïve schizophrenia: evidence for differential susceptibility?

PloS one - 1 Jan 2014

Kalmady Sunil Vasu, Venkatasubramanian Ganesan, Shivakumar Venkataram, Gautham S, Subramaniam Aditi, Jose Dania Alphonse, Maitra Arindam, Ravi Vasanthapuram, Gangadhar Bangalore N

Abstract excerpt

BACKGROUND: Various lines of evidence including epidemiological, genetic and foetal pathogenetic models suggest a compelling role for Interleukin-6 (IL-6) in the pathogenesis of schizophrenia. IL-6 mediated inflammatory response triggered by maternal infection or stress induces disruption of prenatal hippocampal development which might contribute towards psychopathology during adulthood. There is a substantial...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 24787542
DOI: 10.1371/journal.pone.0096021
PMCID: PMC4008499

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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