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Temporal changes in brain morphology related to inflammation and schizophrenia: an omnigenic Mendelian randomization study.

Psychological medicine - 1 Jul 2024

Liu Yunjia, Ren Hongyan, Zhang Yamin, Deng Wei, Ma Xiaohong, Zhao Liansheng, Li Xiaojing, Sham Pak, Wang Qiang, Li Tao

Abstract excerpt

BACKGROUND: Over the past several decades, more research focuses have been made on the inflammation/immune hypothesis of schizophrenia. Building upon synaptic plasticity hypothesis, inflammation may contribute the underlying pathophysiology of schizophrenia. Yet, pinpointing the specific inflammatory agents responsible for schizophrenia remains a complex challenge, mainly due to medication and metabolic status....

Topics

Humans
Schizophrenia
Mendelian Randomization Analysis
Inflammation
Genome-Wide Association Study
Brain
Polymorphism, Single Nucleotide
C-Reactive Protein
Cytokines
Magnetic Resonance Imaging

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

White Matter

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Open in PubMed Open full text

Identifiers

PMID: 38445386
DOI: 10.1017/S003329172400014X
PMCID: PMC11413356

Genes

CRP
CCL7
CXCL1
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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