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Article

Evaluation of an anxiety-related phenotype in galanin overexpressing transgenic mice.

Journal of molecular neuroscience : MN - 1 Jan 2000

Holmes Andrew, Yang Rebecca J, Crawley Jacqueline N

Abstract excerpt

Understanding the role of neuropeptides in mediating emotional behaviors is an important avenue for discovering novel drug targets for anxiety disorders. A role for galanin in mediating anxiety-related behavior is suggested by the pattern of distribution in the CNS and the coexistence of galanin with norepinephrine in the locus coeruleus. Studies in rats have shown that central administration of galanin modulates...

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Source

Identifiers

PMID: 11931346
DOI: 10.1385/JMN:18:1-2:151

Genes

GAL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Evaluation of an anxiety-related phenotype in galanin overexpressing transgenic mice.PMID 11931346Read ↗

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Elimination of galanin synthesis in noradrenergic neurons reduces galanin in select brain areas and promotes active coping behaviorsSemantic proximity Read ↗

Phenotypic assessment of galanin overexpressing and galanin receptor R1 knockout mice in the tail suspension test for depression-related behavior.Semantic proximity Read ↗

Neuroendocrine profiles in galanin-overexpressing and knockout mice.Semantic proximity Read ↗

Phenotypic analysis of GalR2 knockout mice in anxiety- and depression-related behavioral tests.Semantic proximity Read ↗

Generation and phenotypic characterization of a galanin overexpressing mouse.Semantic proximity Read ↗

Identification of glyoxalase-I as a protein marker in a mouse model of extremes in trait anxiety.Semantic proximity Read ↗

Chronic environmental or genetic elevation of galanin in noradrenergic neurons confers stress resilience in miceSemantic proximity Read ↗

Measuring normal and pathological anxiety-like behaviour in mice: a review.Semantic proximity Read ↗

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