Article
Mutation of the Emx-1 homeobox gene disrupts the corpus callosum.
Developmental biology - 25 Aug 1996
Qiu M, Anderson S, Chen S, Meneses J J, Hevner R, Kuwana E, Pedersen R A, Rubenstein J L
Abstract excerpt
Expression of the Emx-1 homeobox gene is largely restricted to the developing and mature cerebral cortex. To study its function, two lines of mice were generated using gene targeting methods that have a deletion that includes the N-terminal coding region of Emx-1. Mice homozygous for the deletion were viable and fertile and exhibited no obvious behavioral defects. However, 100% of homozygous mice lack most or all...
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