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Article

Quasi-digital PCR: Enrichment and quantification of rare DNA variants.

Biomedical microdevices - 1 Aug 2014

Sundberg Scott O, Wittwer Carl T, Zhou Luming, Palais Robert, Dwight Zachary, Gale Bruce K

Abstract excerpt

Rare variant enrichment and quantification was achieved by allele-specific, competitive blocker, digital PCR for aiming to provide a noninvasive method for detecting rare DNA variants from circulating cells. The allele-specific blocking chemistry improves sensitivity and lowers assay cost over previously described digital PCR methods while the instrumentation allowed for rapid thermal cycling for faster...

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PMID: 24781884
DOI: 10.1007/s10544-014-9866-0

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BRAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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