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Article

G-protein stimulatory subunit alpha and Gq/11α G-proteins are both required to maintain quiescent stem-like chondrocytes.

Nature communications - 30 Apr 2014

Chagin Andrei S, Vuppalapati Karuna K, Kobayashi Tatsuya, Guo Jun, Hirai Takao, Chen Min, Offermanns Stefan, Weinstein Lee S, Kronenberg Henry M

Abstract excerpt

Round chondrocytes in the resting zone of the growth plate provide precursors for columnar chondrocytes and have stem-like properties. Here we demonstrate that these stem-like chondrocytes undergo apoptosis in the absence of the receptor (PPR) for parathyroid hormone-related protein. We examine t...

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Source

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Identifiers

PMID: 24781502
DOI: 10.1038/ncomms4673
PMCID: PMC4154354

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24781502-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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