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Caveolin-1 Regulates Genomic Action of the Glucocorticoid Receptor in Neural Stem Cells

29 Apr 2014

Abstract excerpt

While glucocorticoids (GCs) are used clinically to treat many conditions, their neonatal and prenatal usage is increasingly controversial due to reports of delayed adverse outcomes, especially their effects on brain development. Such alterations may reflect the impact of GCs on neural progenitor/stem cell (NPSC) function. We previously demonstrated that the lipid raft protein caveolin-1 (Cav-1) was required for...

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PMID: 24777604
DOI: 10.1128/mcb.01121-13

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